A tissue microarray study of toll‑like receptor 4, decoy receptor 3, and external signal regulated kinase 1/2 expressions in astrocytoma.
Indian J Pathol Microbiol
;
2016 July-Sept 59(3): 294-300
Artigo
em Inglês
| IMSEAR
| ID: sea-179548
ABSTRACT
Introduction:
Decoy receptor 3 (DcR3) functions as a death decoy inhibiting apoptosis mediated by the tumor necrosis factor receptor family. It is highly expressed in many tumors and its expression can be regulated by the MAPK/ ERK signaling pathway and ERK is a vital member of this pathway. Toll‑like receptor 4 (TLR4) is expressed on immune cells. Increased TLR4 expression has been associated with various types of cancers. Material andMethods:
The study was conducted to investigate the expression of DcR3, ERK1/2, and TLR4 in astrocytomas and evaluate if they are validating markers for discriminating glioblastoma from anaplastic astrocytoma in limited surgical specimen. Expression of DcR3, ERK1/2, and TLR4 was determined by immunohistochemical staining of tissue microarray from 48 paraffin‑embedded tissues. A binary logistic regression method was used to generate functions that discriminate between anaplastic astrocytomas and glioblastomas.Results:
The expression of TLR4 and DcR3 was significantly higher in glioblastomas than in anaplastic astrocytomas. DcR3 could discriminate anaplastic astrocytomas from glioblastomas with high sensitivity (93.8%), specificity (90%), and accuracy (92.3%).Conclusion:
Our results suggest that DcR3 may be a useful marker for discriminating anaplastic astrocytomas from glioblastomas.
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Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2016
Tipo de documento:
Artigo
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