Insulin Resistance: Detection By Fasting Insulin In North Indian Obese Adults.

ABSTRACT

Background&objectives:Several studies have shown that obesity is closely related to Insulin resistance(IR). Insulin resistance has been suggested as a primary cause for metabolic syndrome. Identifying such individuals would help to prevent progression of comorbidities associated with IR. Hence present study was planned to assess the importance of Fasting Insulin(FI) as a measure of IR and to analyze its correlation with other indirect methods for the assessment of IR . Methods: Study was conducted in fifty obese and overweight subjects.Body Mass Index of all subjects was calculated . Blood glucose, and FI were assayed after twelve hours of fasting. Homeostasis model assessment (HOMA) and Quantitative insulin sensitivity check indices (QUICKI) were calculated. Results: Present study showed that 90% of subjects had IR by HOMA and QUICKI.Correlation of FI with HOMA and QUICKI was statistically significant (P < 0.05). FI test had significant sensitivity and specificity when compared with HOMA and QUICKI indices. Validity of FI was further analyzed by Cohen’s kappa test and had good agreement (κ =0.67). Conclusion: FI was sensitive and also specific as HOMA and QUICKI in assessment of IR in obese. Thus, FI can be used as a simple test and feasable tool to detect IR in obese subjects. [AnshuKhatri NJIRM 2016; 7(5)1-4]