Immunological Profiles of Mice Protected from Chlamydia-induced Infertility by Anti-caspase Treatment.
Br J Med Med Res
;
2016; 15(3): 1-9
Artigo
em Inglês
| IMSEAR
| ID: sea-183011
ABSTRACT
The study is to investigate the effect of anti-caspase treatment on anti-chlamydia immune response in mice. Both the humoral and aspects of cell-mediated immune response against Chlamydia trachomatis were studied. Antibody response was measured using the ELISA technique to identify all common isotypes, and cytokine response was measured using the PCR technique. The antibody levels (IgG, IgG1, IgG2a and IgA) in Z-VAD-FMK treated group were significantly higher than non-treated group. ELISA results [showed a significantly higher amount of antibodies (IgG, IgG1, Ig G2a and IgA)] were produced in the mice that were pre-treated with Z-VAD-FMK before infection with Chlamydia trachomatis compared to mice post treated with Z-VAD-FMK after Chlamydia trachomatis infection. Data of the study indicate that the caspase inhibitor, Z-VAD-FMK did not negatively affect humoral and T cell mediated immune responses against C. trachomatis in mice.
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Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
Br J Med Med Res
Ano de publicação:
2016
Tipo de documento:
Artigo
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