Levels of Liver Markers in Textile Processing and Dyeing Industry Workers

ABSTRACT

Background: The textile dyeing industries has been condemned as being one of the world’s most offenders in terms of pollution. The workers from textile processing and dyeing industry are exposed to various processing chemicals, dyes and different pollutant for long term which may causing hazardous effects on various organs like particularly lung, liver, kidney have become important issue and less data available which explain the effects of these chemicals on biochemical parameters. Aim and Objectives: The aim of this study is to estimate the levels of Liver function markers in textile processing and dyeing industry and healthy controls. Materials & Methods: In this study, 95 subjects working in textile processing and dyeing industry more than 5 years and 95 healthy controls of both gender matching in age and sex were included. The analysis of biochemical parameters was done by using standard grade reagents and chemicals. Serum Bilirubin, Serum Glutamate Oxaloacetate Transaminase (SGOT/AST), Serum Glutamate Pyruvate Transaminase (SGPT/ALT), Alkaline Phosphatase, Serum Protein, Albumin, were assayed by autoanalyzer using diagnostic reagent kit. Results: In the present study Mean of serum bilirubin, SGOT, serum SGPT and alkaline phosphatase is more in Textile processing and dyeing  industry workers than controls. There was no significant change in mean difference of serum proteins, serum albumin and serum globulin (P > 0.05) but highly significant change seen in serum albumin (P = 000) as compared to control. Conclusion: Significant changes were observed for various parameters like serum bilirubin, SGOT, SGPT, alkaline phosphatase, serum proteins are associated with the increased risk of dysfunction of the liver among the textile processing and dyeing industry workers. Increased awareness and early diagnosis of the exposure to toxic substances in textile processing and dyeing industries are essential for performing prompt management, improving clinical outcomes.