Ofloxacin and Nitrofurantoin sensitivity pattern In Patients of Urinary Tract Infection (UTI) at a tertiary care teaching hospital

ABSTRACT

Introduction: UTIs are the second most common bacterial infection in present population. Women are more prone to UTI than Male.  Uropathogenic Escherichia coli is responsible for >80% of community acquired UTIs. Aims: The present study was carried out to compare sensitivity / Resistance between Ofloxacin and Nitrofurantoin in UTI patients. Methods: This was a prospective, cross-sectional, observatory study conducted on patients (n = 200) suffering from Urinary Tract Infection from March 2014 to February 2015 at the Department of Microbiology and Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre (TMMC & RC), at a tertiary care teaching hospital, in Moradabad, Uttar Pradesh, India. Results: UTI was much more common in females (61%, n=122) than in males (39%, n=78).   The most common organism isolated was E. coli, 47%(n=94),  followed by Klebsiella 34.5%(n=69), staphylococcus 7.5%(n=15), Proteus, pseudomonas 4%(n=8)  and enterococcus 3%(n=6). E. coli was highly sensitive to the Ofloxacin 18% (n=36). Conclusion: Sensitivity pattern of the antimicrobial was found to be more in Nitrofurantoin (57%) was found to be more sensitive than Ofloxacin (40.5%) for the treatment of UTI.