Evaluation of Androgen Receptor in Breast Carcinoma and its Correlations with Er, Pr, Her2/Neu, Triple Negative Receptor Status and Clinical Parameters

ABSTRACT

Background: Breast cancer is the second most common malignancy in Indian women. Among the members of the steroid receptor superfamily the role of estrogen and progesterone receptors (ER and PR) is well established in breast cancer in predicting the prognosis and management of therapy, however, little is known about the clinical significance of androgen receptor (AR) in breast carcinogenesis. The present study was aimed to evaluate the expression of AR in breast cancer and to elucidate its clinical significance by correlating it with other hormonal receptors and clinical parameters. Methods: It was a prospective study which include 30 patients of histopathologically proven breast cancer  admitted to department of surgery at  S.N Medical College Agra .Expression of AR, ER, PR, HER2/ neu receptor  by immunohistochemistry (IHC) and clinical parameters were studied. Results: AR expression is related to ER(P<0.015), PR(p<0.008) and triple negative breast cancer patients (p <0.008). There is significant correlation between AR and menopausal status(p<0.006) while  no significant correlation was found with age and parity. Conclusions: Since there is significant association of AR  in triple negative and post-menopausal women so we can say that AR expression possibly help in confirming their predictive role for therapeutic response in breast cancer patients