A Potent Regimen For Oral Lichen Planus: A Review

ABSTRACT

Background:Oral lichen planus (OLP) is a chronic inflammatory disease that affects oral mucosa. Substantial fluctuation is seen between the patients in response to various treatments posing difficulty for the physician in management of the disease. Aim: To assess efficacy of any form of intervention used to manage oral lichen planus. Materials and methods: All the published randomised control trials from 2000 to 2016 in the management of OLP, comparing active interventions with or without placebo irrespective of age, gender were selected from Cochrane central register of controlled trials, CENTRAL, EMBASE and MEDLINE were included in the study, and SWOT analysis was performed. Results and conclusion: Thirty two randomised control trials using different drug interventions were included in this systematic review. The superiority of corticosteroids in remission of clinical signs of OLP is evident, though with few side effects. Future research with consistent parameters and newer formulations, directed towards personalised medicine are required in a quest of the potent regime to treat this condition.