Prevalence Of Vitamin D Deficiency And To Evaluate The Efficacy Of Vitamin D Granules 60,000 Iu Supplementation In Vitamin D Deficient Apparently Healthy Adults In Urban Areas

ABSTRACT

Healthy adults were screened for 25(OH)D by Enzyme linked immunoassay method. Those found to be deficient or insufficient in vitamin D (defined as 25(OH)D <30 ng/ml) were supplemented with oral vitamin D granules 60,000 IU/week for eight weeks. Serum 25(OH)D level was 3 estimated at the end of 8 weeks. Results: A total of 100 subjects (age 20-50 years) were enrolled for the study. Baseline data and follow up data was available for 90 subjects who consumed a total of eight sachets as per the study protocol. Of these 90 subjects, 91% subjects were found to be vitamin D deficient (<20 ng/ml) , 8.89% were vitamin D insufficient and 0.11% were vitamin D sufficient. The mean plasma vitamin D 25(OH)D level was 12.43 ng/ml (±4.29) at baseline. At the end of the study, the mean 25(OH)D plasma level was noted to be 46.34 ng/ml (±13.57). The mean change from baseline was 23.91 ng/ml (±13.25). Conclusion: This study showed that vitamin D deficiency is highly prevalent in the urban healthy adult population. Eight weeks of vitamin D3 60,000 IU/week oral granules supplementation increased serum 25(OH) D to optimal levels.