Effect Of Risperidone And Clozapine On Executive Functions In First Episode Schizophrenia

Aims:To compare the effect of risperidone and cloazpine on executive functioning in treatment naïve first episode schizophrenia. Methods: A total of 55 treatment naïve first episode patients of schizophrenia as per ICD-10 criteria, were enrolled for the study. Baseline assessment for executive functioning was carried out with TMT- A& B. Clozapine and risperidone were used in the range of 200-600mg/ day and 4- 8 mg/day respectively for 6 months. Results: There was significant improvement in executive functioning in both the groups and the results were statistically significant for clozapine on TMT-B. Conclusion: The findings of current study show that both risperidone and clozapine lead to improvement in executive functioning in first episode of schizophrenia and clozapine fared better than risperidone.