Evaluation of hs-CRP levels in acute coronary syndromes

Background: The incidents of CAD is increasing alarmingly and evidence is emerging about the role of novel risk factors. hs-CRP is emerging as a crucial risk factor for premature atherothrombosis and cardio vascular events. Elevated hs- CRP concentrations early in Acute Coronary Syndrome (ACS), prior to the tissue necrosis, may be a surrogate marker for cardiovascular co-morbidities. Aim: This study was undertaken to measure the levels of serum hs-CRP in patients with CAD as established by CAG. Materials and methods: This study included 100 patients admitted in General Medicine and Cardiology departments with a spectrum of coronary artery disease and undergoing coronary angiography. Routine blood investigation, ECG, Chest cardiograph, and 2D Echo test were performed. Results: A total 100 patients established that hs-CRP were elevated in all the patients irrespective of risk factor status. Also there was statistically significant difference between the levels of hs-CRP and angiographic extent of lesion. hs-CRP levels were also found to be higher in in patients with positive family history of CAD and elevated LDL-C, decreased HDL-C. Conclusion: measurement of hs-CRP should not be used as an alternative for but as an adjunct to major risk factors in assessing and thus better define the intensity of preventive therapies to be initiated