A case control analysis to find association between PCO and endometrial carcinoma (EC)

ABSTRACT

Background: Endometrial cancer is one of the commonest cancers in women. Unopposed estrogen stimulation of the uterus is amongst one of the etiologies postulated for this condition. It is generally assumed that women with polycystic ovary syndrome are more likely to develop endometrial carcinoma. Aim: This study hypothesized comparing the ovarian morphology of women diagnosed with endometrial carcinoma and those with benign gynecological conditions. Materials and methods: The present study included a total 64 patients who had been diagnosed with endometrial carcinoma and with 42 age matched control. All biopsy samples were undergone routine histological process with Hematoxylin-Eosin stain to check morphological differentiation. Results: There was found no significant difference in the prevalence of PCOS (using this as a marker of PCOS in the absence of information on biochemistry) in the ovaries of patients diagnosed with endometrial cancer compared to women with benign gynaecology disease. Conclusion: Although our numbers were small, these results challenge the assumption that PCOS is a risk factor for endometrial cancer. Investigation of patient records revealed there was no significant difference in the demographic profile between subjects with endometrial carcinoma or benign gynecological conditions.