Study of Mast Cells in Non Neoplastic Skin Conditions

ABSTRACT

Introduction: Mast cells are always been a fascinating field of research workers working with inflammatory processes, Hypersensitive disorders, and hosts defence mechanisms. Wide variation in mast cell counts and blood density is noticed in different sections of the skin in same biopsy sample. Aim and objectives: To assess the pattern of mast cell arrangement in various non- neoplastic skin lesions and compared with normal skin biopsies, to analyze the pattern of mast cell distribution in various non-neoplastic lesions of the skin, to compare with quantum of mast cells in various nonneoplastic lesions. Materials and methods: A study was conducted for 10 years from March 2006 to February 2016, which included all non-neoplastic skin conditions were subjected for mast cell count and distribution in the Department of Pathology at Gandhi Medical College/ Hospital with collaboration with Dermatology Department. The biopsy specimens were processed and stained with routine H&E and special stain for mast cells Toluidine Blue. The mast cells counted with the help of ocular micrometer under the microscope. Results: About 1000 non-neoplastic lesions grouped into 11 categories and mast cell count was done. Irrespective of the category, Urticaria pigmentosa showed highest mast cell count (144/sqmm). Nevus comedonicus showed lowest count (13/sqmm). Conclusion: The role of mast cells in health and disease is significant and distinct alterations of mast cell are present in various non-neoplastic conditions.