A Study on Lipid Profile in Hypothyroidism in South India

ABSTRACT

Background:Hypothyroidism is a syndrome characterized by clinical and biochemical manifestations which results from decreased production of thyroid hormones. Aims and Objectives: To Study Lipid Profile of patients with hypothyroidism. Methods: This study conducted in 80 hypothyroidism patients in different areas in Andhra Pradesh Between Jan 2013 to Dec 2015. Hypothyroidism is diagnosed by estimation of T3T4TSH. Serum Cholesterol , serum triglycerides HDL cholesterol and LDL cholesterol were estimated. About 93% of thyroid hormone in thyroxin (T4) and 7% is Triido thyronin (T3). There are 3 deiodinase enyymes (D1 D2 & D3) D1 and D2 are responsible for peripheral conversation of T4 to T3.Results: The maximum incidence of age is between 20-40 years with 65%. The age group is almost same in males and female. Sex incidence is (51) males female ratio is 15. TSH is more than 12 mu/L in 80 patients The mean serum cholesterol value is more than 245 mg/dl The mean value for serum HDL is 42 mg/dl and LDL is 130 mg/dl . The mean value for serum triglyceride is 250 mg/dl. Among thyroid hormones T3 is between 50 to 70 ng/dl (normal is 95-195 ng/dl) T4 is 2-4 mcg/dl (normal is 5-11 mcg/dl) and TSH is >12 micro units/ml (normal is 0.4 to 4 micro units/ml).The Serum cholesterol is high in 50 patients (60%) 20 patients (25%) has border time and 10 patients (15%) desirable level according to ATPIII guidelines by NCEP. S. triglycerides level was high in 55 patients (70%). Conclusion: Hypothyroidism causes increased total cholesterol increases LDL and increased. triglycerides. This Dyslipidemia cause coronarys artery disease . So the treatment with L- thyroxine is indicated to prevent coronary artery disease.