To Study the Effect of Antiepileptic Drugs on Serum Alkaline Phosphatase Levels in the Epileptic Patients

ABSTRACT

Epilepsy is treated with anti-epileptic drugs (AEDs) mainly in most of the patients. AEDs are to be initiated after having 2 seizures within a 6-month period. These have been observed to be associated with an increased frequency of hypocalcemia, hypophosphataemia, elevated serum alkaline phosphatase activity, reduced 25-hydroxy Vitamin-D concentrations, and decreased bone mass in patients receiving long term therapy. It is also observed that duration of AED therapy was the most important contributing factor for the alterations of these biochemical parameters. Objective: To study the effect of antiepileptic drugs on serum alkaline phosphatase levels in epileptic patients and to compare the relationship of change with duration of drug intake. Study Design: A Case Control Prospective Study. Methods: A total number of 100 subjects presenting with epilepsy in the OPD of Neurology department of Guru Nanak Dev Hospital, attached to Government Medical College Amritsar, were selected. Results: 50 epileptic patients taking Antiepileptic Drugs for more than 6 months constituted case group and 50 epileptic patients not taking Antiepileptic Drugs constituted control group. The study group patients were further divided according to duration of drug intake. Conclusion: AEDs causes significant increase in Alkaline phosphatase levels and this increase is further related to duration of drug intake.