Multiple Osseous Metastases in Malignant Phyllodes Tumor

ABSTRACT

Introduction: Phyllodes Tumors (PT) arises from intralobular stroma of breast, accounts for 0.3 to 1% of all primary breast cancers. Only few cases of PT metastatic to bone have been reported so far. Case report A 33 years old female was presented with a 3 month history of pain and swelling of right thigh and functional deformity of right leg. She had a past history of post lumpectomy with metastasis to left iliac bone; histopathology was suggestive of malignant phyllodes tumor (MPT). She had a pathological fracture of her right femur. Later she developed metastases to multiple bones. Palliative irradiation was considered for left iliac bone, right femur and right scapular metastasis. She then received adriamycin and ifosfamide chemotherapy and zolendronic acid. Currently, she has no symptoms and in a stable condition. Conclusion: MPT is an aggressive neoplasm of the breast with high rates of local recurrence and distant metastases. The limited role of surgery, chemotherapy and irradiation gives a poor prognosis. The metastases occur in a swift manner and average survival is less than 2 years.