Effect of antibiotics on polymorphonuclear function in iron deficiency anaemia patients & normal volunteers.
Artigo
em Inglês
| IMSEAR
| ID: sea-19142
ABSTRACT
The effect of erythromycin and gentamicin on polymorphonuclear leukocyte (PMN) functions was assessed in normal individuals and in patients with iron deficiency anaemia (IDA) before and after treatment with iron. The PMN phagocytic function was investigated by the standard method. Erythromycin in vivo significantly increased the PMN phagocytic function from 44.18 +/- 2.08 to 57.0 +/- 1.5 at 8 h and the bactericidal activity from 48.33 +/- 1.97 to 56.7 +/- 0.89 at 8 h in the normal adult male volunteers. A significant increase in phagocytic and bactericidal function of PMNs from IDA patients was also observed after in vivo administration of erythromycin. Gentamicin in vitro reduced the bactericidal activity of PMN from normal volunteers (P less than 0.05) but increased the PMN phagocytic activity in normal volunteers and IDA patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fagocitose
/
Atividade Bactericida do Sangue
/
Humanos
/
Masculino
/
Gentamicinas
/
Eritromicina
/
Adulto
/
Avaliação de Medicamentos
/
Anemia Hipocrômica
/
Neutrófilos
Idioma:
Inglês
Ano de publicação:
1991
Tipo de documento:
Artigo
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