Salivary Antioxidant Status Following Radiotherapy In Patients With Head And Neck Cancer

ABSTRACT

Background: Head and neck cancer (HNC) represents 3% of all the malignant tumours. It is the sixth most commonhuman malignancy. Patients with head and neck cancer receiving radiotherapy are exposed to ionizing radiationwhich may damage normal tissue located in the field of radiation. The present study aims to determine thechanges in antioxidants status of pre and post RT saliva samples of HNC patientsMaterials and Methods: The pre and post radiotherapy saliva samples were collected from every patient withhead and neck cancer. The changes in the antioxidant levels of saliva in pre and post radiotherapy salivasamples of head and neck cancer patients was determined.Observation The three biochemical parameters levels Malondealdehyde, Glutathione peroxidase,Myeloperoxidase decreased following radiotherapy. But the decrease was not statistically significant forGlutathione peroxidase and Myeloperoxidase and highly significant for Malondealdehyde.Conclusion: The Total Antioxidant Capacity increased following radiotherapy and it was observed that afterradiotherapy their increased levels were statistically not significant.