Peripheral blood lymphocyte subsets in idiopathic nephrotic syndrome of childhood.
Artigo
em Inglês
| IMSEAR
| ID: sea-19918
ABSTRACT
Lymphocyte subsets in the peripheral blood were examined in 34 patients with nephrotic syndrome [27 with minimal change nephrotic syndrome (MCNS), 7 with significant lesions] and 10 normal children. The investigations were done at the onset of disease before administering corticosteroids (n = 34), during the subsequent remission (n = 27), and the first relapse (n = 12). The proportions of T cell subsets (CD3, CD4 and CD8) were determined by immuno-alkaline phosphatase staining; interleukin-2 receptor (IL-2 R) positive cells, natural killer (NK) cells and B cells were studied by indirect immunofluorescence. No significant differences were found in the proportion of CD3, CD4, CD8 and IL-2 R positive cells in patients with MCNS as compared to controls. An increased proportion of NK and B cells was not specific to MCNS and was detected even in those with significant renal lesions. Our findings suggest that T lymphocyte subsets in MCNS are similar to those in normal children.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Estudos de Casos e Controles
/
Criança
/
Pré-Escolar
/
Subpopulações de Linfócitos
/
Adolescente
/
Lactente
/
Nefrose Lipoide
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Ano de publicação:
1996
Tipo de documento:
Artigo
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