Predictors of Mortality among Neonates with Congenital Diaphragmatic Hernia: Experience from an Inborn Unselected Cohort in India
Indian Pediatr
;
2019 Dec; 56(12): 1037-1040
Artigo
| IMSEAR
| ID: sea-199448
ABSTRACT
Objective:
To evaluate the clinical profile and predictors of mortality in neonates withcongenital diaphragmatic hernia (CDH).Method:
Demographic and clinical parameters ofneonates with congenital diaphragmatic heria (n=37) between January 2014 and October,2017 were reviewed, and compared among those who survived or expired in hospital.Result:
Median (range) gestation and birthweight were 38 (37-39) weeks and 2496 (2044-2889) g, respectively. Persistent pulmonary hypertension (PPHN) was documented in 19(51%) neonates and 10 (27%) had associated malformations. Surgery could be performed in18 (49%), overall mortality was 60%. On univariate analysis, low Apgar scores, presence ofmalformations, PPHN, need for higher initial peak inspiratory pressure/high frequencyventilation, and requirement of a patch for closure were associated with increased mortality.On multivariate analysis, PPHN remained the only significant risk factor [adjusted RR 3.74(95% CI 1.45-9.68)].Conclusion:
The survival of infants with CDH is low, and PPHN is animportant predictor of mortality.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Revista:
Indian Pediatr
Ano de publicação:
2019
Tipo de documento:
Artigo
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