Effect of pregnancy on protection of mice immunized by Japanese encephalitis virus & its experimental inactivated vaccine.

The effect of pregnancy on the protective immune response of mice to tissue culture-derived inactivated Japanese encephalitis (JE) Nakayama vaccine and to live sublethal doses of JE virus, was studied. Thirty per cent protection was found in mice, immunized with three doses of inactivated vaccine, before pregnancy and challenged after delivery. In contrast, all the mice immunized with two sublethal doses of JEV tolerated the challenge under similar condition.