Spectrum of Mucocutaneous Manifestations among Patients with Various Liver Disorders

ABSTRACT

Introduction: Skin is the first barrier against any externalagent and a reflection of any deviation in the internal milieu.Any systemic disorder or organ dysfunction can leaveits imprints on the skin and so also the liver certainly hascutaneous manifestations in case of any disorder affecting it.Study objective was to investigate the spectrum of cutaneousmanifestations of various liver disorders and liver diseasespecific association.Material and methods: A total of 220 patients with primaryliver disorders were taken up for the study after proper ethicalclearance. A detailed clinical history was taken from thepatients regarding liver disorder and cutaneous symptoms. Athorough clinical examination was done and all specific andnonspecific cutaneous manifestations were recorded.Results: Out of 220 patients, 135(61.3%) were males and85(38.6%) were females with a male preponderance. Amongthe various liver disorders, most commonly seen was alcoholicliver disease seen in 84(38%) patients, nonalcoholic fatty liverdisease (NAFLD) and nonalcoholic steatohepatitis(NASH)in 51(23.2%) patients, cirrhosis in 35(16%) patients. Themost common cutaneous manifestation seen was icterus in190(86.3%) patients, pruritus in 178(80.9%) patients, xerosisin 112(51%) patients.Conclusion: The knowledge of the cutaneous manifestationsin liver disorders can be of great help as many liver disorderscan easily be detected at their incipient stage. This study wasdone to assess the spectrum of cutaneous manifestations inliver disorders and a significant observation made was liverdisease wise specific evaluation of cutaneous manifestationsthus providing better insight into the type of liver diseases.