Mitoxantrone & adriamycin cytotoxicity enhanced by reserpine in human chronic myeloid leukaemia cells.
Artigo
em Inglês
| IMSEAR
| ID: sea-20272
ABSTRACT
The effect of reserpine was studied alone and in combination with anticancer drugs on human chronic myeloid leukaemia (CML) cells. To study the effect of reserpine on anthracycline antibiotic adriamycin and anthracenedione mitoxantrone the extent of 3H-thymidine incorporation into the DNA was taken as the measure of cytotoxicity. The results indicate that reserpine enhances the cytotoxicity of mitoxantrone and adriamycin in mildly toxic concentrations (1 and 10 micrograms respectively), in CML cells. The mechanism of enhancement in drug sensitivity by reserpine in CML cells is due to enhanced intracellular accumulation of drug.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Reserpina
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Humanos
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Ensaios de Seleção de Medicamentos Antitumorais
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Células Tumorais Cultivadas
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Leucemia Mielogênica Crônica BCR-ABL Positiva
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Protocolos de Quimioterapia Combinada Antineoplásica
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Doxorrubicina
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Sobrevivência Celular
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Mitoxantrona
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Sinergismo Farmacológico
Idioma:
Inglês
Ano de publicação:
1989
Tipo de documento:
Artigo
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