Propofol and Ketamine in Electroconvulsive Therapy Anesthesia: A Randomised Controlled Study

ABSTRACT

Introduction: Currently, the effects of combined anesthesia(propofol and ketamine) for patients with depressive disorderwho have undergone electroconvulsive therapy (ECT) areunclear. Study aimed to evaluate the effect of ketamine,propofol, and ketofol on hemodynamic profile, duration ofseizure activity, and recovery times in patients undergoingECT.Material and methods: Sixty patients who were scheduledfor ECT treatment were enrolled. The study population wasrandomly assigned to receive one of three anesthetic agentsketamine, propofol, or ketofol. The required total dose of thethree agents was recorded. Mean arterial pressure (MAP),heart rate (HR), and oxygen saturation values were recordedat baseline, at induction, and at 1, 3, 5, and 10 min after theend of seizure.Results: We found that both ketamine and ketofol have anincreased mean seizure duration compared to propofol, ketofolhad more favorable hemodynamic effects than ketamine andpropofol, and ketamine was found to have longer recoverytimes compared to both propofol and ketofol.Conclusion: We found that both ketamine and ketofol have anincreased mean seizure duration compared to propofol.