Clinical, Hormonal and Metabolic Profile of Different Phenotypes of Polycystic Ovarian Syndrome

ABSTRACT

Background: Polycystic ovarian syndrome (PCOS) is one ofthe most frequently encountered hormonal disorder withmetabolic abnormalities in females that can present at puberty,during reproductive age or even after menopause. Therefore,the aim of this study was to evaluate the occurrence of differentphenotypes among PCOS women and to compare thehormonal assay and metabolic profile of different phenotypesof PCOS.Materials & Methods: The present study was an observationalstudy conducted on 160 women of the age group of 16-35years and diagnosed with PCOS, in the department ofobstetrics and Gynecology at Mahatma Gandhi MedicalCollege and Hospital, Jaipur from January 2017 to July 2018.Diagnosis of PCOS was done by using the ESHRE/ASRMcriteria and subjects were divided into 4 phenotypes by usingthe all probable combination of Rotterdam criteria. Hirsutismwas assessed by using Modified Ferriman Gallwey score.Score <8 - Normal, 8-15- Mild and >15 indicate moderate tosevere hirsutism.Results: 160 PCOS women were distributed in 4 phenotypesand the most prevalent phenotype was phenotype D, 40.63%followed by 32.50% phenotype A and 14.38% phenotype C.Mean age of overall women was 24.94±4.86. In this studyoverall prevalence of metabolic syndrome was 37.5%. Almost50% women of phenotype A had metabolic syndrome followedby 35% of phenotype B, 34.78% of phenotype C and leastprevalence was in phenotype D 30.77%.Conclusion: We concluded that the most prevalent phenotypeis nonhyperandrogenic phenotype 40.63% and least commonphenotype is classic nonpolycystic ovaries phenotype(12.50%).