Cytohistopathological and ImmunohistochemicalCorrelation of Soft Tissue Lesions

ABSTRACT

Introduction: In the present era, FNAC has proved to be anessential primary diagnostic procedure for soft tissue lesions.To correlate its efficacy and to further subtype,histopathological examination is done aided by IHC if required.The present study aimed to evaluate the epidemiologicaldistribution of soft tissue lesions with reference to age, sex andsite and to assess the utility of FNAC in terms of sensitivity,specificity, positive and negative predictive values, and overallhistological correlation percentage of cytology in diagnosingvarious types of soft tissue lesions.Materials and Methods: Prospective study was carried outduring the period of Sept 2017 to May 2019 for FNAexamination of soft tissue lesions. Cytopathological andhistopathological examination was carried out in all cases withimmunostaining done in few cases.Results: Of 463 soft tissue lesions that could be successfullyfollowed up, 347 were benign lesions and rest were malignant.Most common age group affected were 31-40 years with slightmale preponderance (MF=1.371). Most common site beingLower extremities. Lipomas were the most common soft tissuelesions (169 cases) and spindle cell sarcomas were the mostcommon malignant lesions. The cytological andhistopathological diagnosis correlated well in almost all casesexcept discordance was seen in 5 cases. The sensitivity andspecificity of the procedure were 97.4% and 99.4%respectively.Conclusion: FNAC was found to be a highly specific andsensitive tool in diagnosing soft tissue lesions and can be fairlyimplemented as it is well tolerated and cost effective forpatients.