An Assessment Of Potential Drug-Drug Interactions In Hypertensive Patients In A Tertiary Care Hospital
Int J Pharm Pharm Sci
;
2019 Mar; 11(3): 32-36
Artigo
| IMSEAR
| ID: sea-205852
ABSTRACT
Objective:
To an assessment of potential drug-drug interactions in hypertensive patients in a tertiary care hospital.Methods:
A prospective, observational study was conducted at a tertiary care hospital, Erode for a period of 8 mo. A sample of 480 patients was assessed for PDDIs using drug checker in Micromedex®-2.7.Results:
A total of 430 patients were analyzed and it was found to be 396 (82.50%) hypertensive patients had PDDIs, and a sum total of 1160 PDDIs were observed. Potential drug-drug interactions (PDDIs) higher in female hypertensive patients [255 (64.39%)] compared to males. Incidences of PDDIs were found to be higher in the age group of 60-70 y were [177 (44.69%)] and incidences of interactions based on the duration of (4-6 d) hospital stays were 272 (68.68%). Moreover, 49.24% of patients were found to be prescribed with more than 7 drugs, with higher incidences of PDDIs. Some of the most common drug interacting pair was between aspirin and clopidogrel combination observed in 325 PDDIs in the major, with pharmacodynamics in nature.Conclusion:
Clinical pharmacist ought to have the role of regular monitoring of drug therapy in identifying and preventing the medications that have the potential to cause drug-drug interactions, thereby minimizing the undesirable outcomes in drug medical care and improving the quality of care.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo observacional
Revista:
Int J Pharm Pharm Sci
Ano de publicação:
2019
Tipo de documento:
Artigo
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