​Histomorphological Spectrum of Pancreatic Carcinoma – A Retrospective Study

ABSTRACT

Introduction: Pancreatic cancer is dominated by exocrine pancreatic cancer. The most common histological type isadenocarcinoma in 95% of cases. Surgery remains the only curative treatment. However, only 20% of pancreatic cancers arejudged to be operable at the time of diagnosis.Aim: The aim of this study was to comprehensively analyze the histopathological spectrum of pancreatic lesions.Materials and Methods: This retrospective study was conducted in all pancreatic lesion cases. The specimens were examinedexternally and then opened as per the conventional method after overnight fixation in 10% formalin.Results: A total of 26 (52%) biopsy samples were obtained, 4 (8%) cyst excision, 11 (22%) partial pancreatectomy, and9 (18%) Whipple’s procedure specimen. Mean tumor size was 2.64 cm range 0.6–13 cm. Of the various gross morphologicaltypes seen, the most common was polypoid. Malignant lesions were 16 (32%) cases of adenocarcinoma, 6 (12%) cases of theneuroendocrine tumor, and 4 (8%) cases of solid pseudopapillary tumor of the pancreas.Conclusion: Histopathology is mandatory in many of the lesions which present as cystic and solid masses. It also aids inavoiding unwanted radical surgeries in patients which will increase the morbidity and mortality.