The phytochemical and chemotaxonomic study of Salvia spp. growing in Ukraine

Salvia officinalis is a well-studied and popular medicinal plant containing toxic thujones, rather limitedphytochemical and pharmacological studies have been performed on other Salvia spp. The aim of the studywas to perform phytochemical and chemotaxonomic studies of Salvia genus species (n = 16) from Ukraineto identify the most promising species for the pharmaceutical industry. The content of essential oils from theleaves of 16 Salvia spp. has been studied by gas chromatography/mass spectrometry (MS) and polyphenols byhigh performance liquid chromatography/MS, and a chemotaxonomic study has been performed by calculationof coefficients of occurrence, originality, and pair affinity. The Salvia spp. is characterized by the presence ofmonoterpenoids, hydroxycinnamic acids – derivatives of caffeic acid, and flavonoids – derivatives of luteolinand apigenin. The highest content of essential oil is observed in the leaves of S. officinalis, S. grandiflora, andS. scabiosifolia (1.41%–1.85%). The highest amount of hydroxycinnamic acids is in the leaves of S. pratensis,S. illuminata, S. austriaca, and S. verticillata; the highest content of flavonoids and phenolic compounds isfound in the leaves of S. grandiflora, S. pratensis, S. illuminata, S. nemorosa, S. pendula, S. sylvestris, S.nutans, S. verticillata, and S. cernua. The chemical profile of the genus has been determined; it is characterizedby terpenoids such as α- and β-pinene, camphane derivatives (camphene, camphor, and borneol), p-cymene,1,8-cineol, limonene, phenolic compounds (caffeic and rosmarinic acids), and flavonoids (cynaroside,cosmosiin, hispidulin, and cirsimaritin). A rather high concentration of toxic _- and _-thujone is typical onlyin the essential oil of S. officinalis (33.6% and 6.5%, respectively). The most promising species for use in thepharmaceutical industry are S. grandiflora, S. cernua, S.pratensis, S. nemorosa, and S. verticillata.