A Clinical and Preliminary Study for Anti-angiogenesis Therapy: Endostatin, VEGF and Microvessel Density in the OSCC in Different Stages and Differentiations

ABSTRACT

Aims: This study was to analyze the association among ES, VEGF,Microvessel Density (MVD),clinicopathologic characteristics, angiogenesis and prognosis of OSCC. Methods: Eight normal samples of oral epithelia and 52 Oral Squamous Cell Carcinoma (OSCC) samples were analyzed by immunohistochemical evaluation to study the expression and significance of Endostatin (ES) and Vascular Endothelial Growth Factor (VEGF) during the development of OSCC. Results: Statisticallysignificant differences were found as p<0.05 between VEGF expressions and clinicopathologic stages of OSCC and as p<0.01 between VEGF expressions and lymph node metastases of OSCC. And Statisticallysignificant discrepancy was also found as p<0.05 between MVD and differentiation degrees and lymphnode metastases of OSCC, as well asp<0.01 between VEGF expressions andMVD. Additionally MVD increased gradually in accordance with the progression of the Cancer. While there was no obvious correlation between ES and VEGF, ES and MVD, as well as between ES and the development of OSCC. Conclusion:By MVD etal evaluation,VEGF is one of the major angiogenesis factors for angiogenesis and lymphonodemetastasis of oral carcinomas, as an important indicator for the development and malignancy of OSCC,while ES is of significance for anti-angiogenesis in tumor therapy