Chromanone-type compounds from marine sponge-derived Daldinia eschscholtzii KJMT FP 4.1

ABSTRACT

In our investigation on chemical diversity of secondary metabolites from marine microorganisms, a sponge-derivedfungus was found to produce a glycosylated aromatic compound, karimanone (1). The fungal strain was isolatedfrom an Indonesian sponge Xestospongia sp. collected in Karimunjawa National Park, Central Java, Indonesia, andwas identified as Daldinia eschscholtzii based on the internal transcribed spacer rRNA gene sequence. Herein, wedescribe the isolation and characterization of karimanone (1), a new chromanone-type compound, along with threebiosynthetically related metabolites 2–4. All compounds were active against a multidrug-resistant strain of Salmonellaenterica ser. Typhi with an MIC of 62.5 μg/ml for compound 2 and 125 μg/ml for compounds 1, 3, and 4.