Stage-specific expression analysis ofMMP-2 & MMP-9 in laryngeal carcinoma
J Cancer Res Ther
;
2020 Jul; 16(3): 517-520
Artigo
| IMSEAR
| ID: sea-213851
ABSTRACT
Aim of the Study Both matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is involved in degradation of extracellular matrix and found to stimulate invasion and metastasis in cancer patients. However, studies on the stage-specific expression of MMPs at different stages of larynx carcinoma are still lacking. In the present study, we compare the expression level of MMP-2 and MMP-9 at different stages of laryngeal carcinoma. Material and Methods:
Tumor tissues samples were taken from larynx cancer patients by deep biopsy during direct laryngoscopy. Gene expression for MMP-2 and MMP-9 was analyzed using RT-PCR.Results:
Significantly high expression of MMP-2 was observed compared to the MMP-9 at stage IV compared to the less advanced stages of the disease.Conclusion:
Present study concluded that the MMP-2 expressed with a greater magnitude as compared to the MMP-9 in advance stages of laryngeal carcinoma
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Revista:
J Cancer Res Ther
Assunto da revista:
Neoplasms
/
Therapeutics
Ano de publicação:
2020
Tipo de documento:
Artigo
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