Correlation of planning target volume with mucositis for head-and-neck cancer patients undergoing chemoradiation
J Cancer Res Ther
;
2020 Jul; 16(3): 565-568
Artigo
| IMSEAR
| ID: sea-213860
ABSTRACT
Context Head-and-neck cancer patients undergoing chemoradiation. Aims:
The aim of the study was to see if there is any correlation between the planning target volume (PTV) and mucositis. Settings andDesign:
This was a single-arm prospective study. Subjects andMethods:
A total of forty head-and-neck cancer patients undergoing chemoradiation were assessed for mucositis at the 5th week. The grades of mucositis were correlated with PTVs of low risk (54 Gy) and high risk (60–66 Gy). Statistical Analysis Used The data were analyzed using the statistical software, SPSS Inc. Release 2009, predictive analytics software statistics for windows version 20.0, Chicago. Log transformation was done as the data were skewed. Independent t-test was used to compare between the two grades of toxicity. P <0.01 was considered for statistical significance.Results:
The mean PTVlow risk was 522cc (228–771) and PTVhigh risk was 254cc (20–780). Grade II mucositis was seen in 27 (67%) patients and Grade III in 11 (28%) patients. The mean PTVlow risk was higher for patients, who had Grade III compared to Grade II mucositis (571 vs. 517 cc, P = 0.052).Conclusions:
The same was seen for PTVhigh risk(367 vs. 222 cc, P = 0.017). PTV is a better predictor of mucositis, and those patients with larger PTV require close monitoring and early intervention of mucositis
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Revista:
J Cancer Res Ther
Assunto da revista:
Neoplasms
/
Therapeutics
Ano de publicação:
2020
Tipo de documento:
Artigo
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