Central alpha-adrenoceptor influence over the cardiovascular reflexes activated by veratrine.
Artigo
em Inglês
| IMSEAR
| ID: sea-21389
ABSTRACT
Intravenous veratrine induced alterations in cardiovascular parameters in cats were used as a tool for assessing the influence of central alpha-adrenoceptors over reflex adjustments in the heart rate and blood pressure. Blockade of central alpha 2-adrenoceptors with idazoxan or yohimbine, inhibited, while their activation by clonidine, as also blockade of alpha 1-adrenoceptors, with prazosin, potentiated the veratrine induced bradycardia. The hypotensive effect was relatively unaltered by these treatments. Low doses of clonidine potentiated the veratrine-induced bradycardia. It appears that alpha 2-adrenoceptor mechanisms exert greater control over the reflex regulation of heart rate than over reflex control of blood pressure.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pressão Sanguínea
/
Veratrina
/
Gatos
/
Receptores Adrenérgicos alfa
/
Frequência Cardíaca
/
Animais
Idioma:
Inglês
Ano de publicação:
1989
Tipo de documento:
Artigo
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