Antibody response to outer membrane proteins in Shigella dysenteriae type 1 infection with special reference to appearance of murine antibodies.
Artigo
em Inglês
| IMSEAR
| ID: sea-21427
ABSTRACT
In shigellosis, the protective immune mechanism is not well established. The bacterial outer membrane proteins (OMPs) may have a role in the induction of immunity due to their outwardly location. The serum antibody response of S. dysenteriae type 1 infected patients against OMPs was assessed by enzyme linked immunosorbent assay (ELISA). A striking elevation of serum IgG response was noted during the convalescent phase. Murine antiserum directed against S. dysenteriae 1 OMPs was found to be highly cross reactive with the OMPs isolated from heterologous species. A major antigenic OMP was partially purified and showed distinct immunodominance in ELISA. These observations suggest that the specific component may have some immunoprophylactic potential.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Shigella dysenteriae
/
Proteínas da Membrana Bacteriana Externa
/
Humanos
/
Imunoglobulina G
/
Ensaio de Imunoadsorção Enzimática
/
Lipopolissacarídeos
/
Reações Cruzadas
/
Disenteria Bacilar
/
Cobaias
/
Animais
Idioma:
Inglês
Ano de publicação:
1996
Tipo de documento:
Artigo
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