Comparison of Pain on Injection of Propofol MCT with Propofol LCT.

ABSTRACT

Propofol is one of the safest drugs for induction of general anaesthesia. Routinely available preparation in the market being propofol LCT (long chain triglycerides) has the disadvantage of pain on injection. This pain is very discomforting for the patient and also to the anaesthesiologist. So, they are coming up with a new preparation propofol MCT (medium chain triglycerides) which causes less pain on injection. We wanted to compare the occurrence of pain on injection of Propofol MCT with Propofol LCT.METHODSAfter obtaining institutional ethical committee approval, 150 patients undergoing various elective surgeries under general anaesthesia where propofol was used as an induction agent, aged between 18 and 65 years of ASA I & II were enrolled in the study. The study patients were divided into two groups. Group M, who received Propofol MCT and group L, who received Propofol LCT as an induction drug. The intensity of pain was evaluated by using Visual Analogue Score (VAS). Similarly change of triglyceride levels after single induction dose of Propofol MCT and Propofol LCT were observed.RESULTSGroup M showed reduced pain score (4.15±1.90) after injection along with less incidence of pain compared to Group L (6.37±2.49). Serum triglyceride levels had no significant difference in preoperative and postoperative values.CONCLUSIONSPain on injection with Propofol MCT (4.15 ± 1.90) is less compared to Propofol LCT (6.37± 2.49) & no evidence of change of triglyceride levels was seen after a single induction dose in the study.