A Study of Placental Changes in Polycystic Ovarian Syndrome Patients with Gestational Diabetic Mellitus

ABSTRACT

Placenta is a vital organ for the development of foetus and maintenance of pregnancy. Placenta helps in the development and growth of foetus in uterus. In between maternal and foetal circulation the transfer of waste products and nutrients was done by the placenta which is a complex organ of a short life span. The diabetic pregnancy is characterised by numerous disturbances in foetal growth and development.METHODSA cross sectional study on placental changes in 60 pregnant women was done over a period of 18 months. Pregnant women in the age group of 25 years to 40 years who were suffering from polycystic ovarian syndrome (PCOS) were included in the study. Placental specimens were collected from obstetrics department and fixed overnight in 10% formalin. Thorough gross examination was done and few bits from the abnormal areas were given for microscopic examination. Routine histopathological process was followed for microscopic examination.RESULTSOut of 60 pregnant women with PCOS, seven patients were found to be having PCOS with gestational diabetes mellitus. These seven patients showed gross and microscopic changes in the placenta when compared with non-diabetic PCOS pregnant women.CONCLUSIONSPlacenta of diabetic women with PCOS showed both gross and microscopic abnormalities which may affect the growth and development of baby during intrauterine life.