A Cross-sectional study on oxidative stress markers in type 2 Diabetes Mellitus and their correlation with blood sugar levels

ABSTRACT

Background: Among major metabolic disorders of glucose metabolism, diabetes mellitus is the most common one, in which Insulin deficiency and insulin resistance are the common observations. It is a renowned fact that long-standing hyperglycaemia is associated with oxidative stress, caused by an increase in the reactive oxygen species. Adenosine deaminase(ADA) is a purine metabolic enzyme that degrades adenosine. Gamma-glutamyl transferase (GGT) maintains antioxidant levels by maintaining reduced glutathione in the cells. Ceruloplasmin is a known acute phase reactant. Aim: 1. To Study and compare the levels of Serum FBS, PPBS, ADA, GGT and Ceruloplasmin in T2DM patients and nondiabetic subjects. 2. To study the correlation between these parameters and blood sugar levels in cases. Materials and methods: A descriptive cross-sectional study was done at Subbaiah medical college in Shimoga, taking 50 T2DM patients and 50 controls. Serum levels of fasting blood sugar(FBS), Postprandial blood sugar (PPBS), Adenosine deaminase, Gamma-glutamyl transferase and Ceruloplasmin were estimated. Data were analysed in SPSS software 17 using independent student t test. p < 0.01 was considered significant. Results: Increased levels of ADA, GGT and ceruloplasmin in cases were found, and they were statistically significant. Pearson correlation of these inflammatory markers with FBS and PPBS showed a positive significant correlation.