Effect of Selenium-yeast on Cognitive Performance on Pregnant Dams Exposed to Noise Stress

ABSTRACT

A total of twelve pregnant Wistar rats were used, and randomly divided into three groups (n=4). Group A (negative control), not exposed to noise stress), group B (1mL/kg of distilled water + 4h /15 days noise stress), group C (0.04 mg/kg) of selenium-yeast + 4 h/15 days noise stress). On day 18 and 19 of gestation cognitive tests were conducted using Y-maze and Novel Object Recognition Test. A significant increase (P ? 0.05) was observed in the percentage alternation and discrimination index in group A compared with group B. However, the percentage alternation and DI were significantly (P ? 0.05) decreased in group C compared with group B. In conclusion, noise stress induces cognitive deficit, this deficit can be mitigated with the administration of selenium-yeast.