Comparison Of Pulse Rate Variability Among Type 2 Diabetics And Normal Individuals

ABSTRACT

Background:Cardiac autonomic dysfunction is one of the most common and serious complication of type 2 diabetesmellitus (DM). Pulse rate variability (PRV) is a simple and non-invasive indicator of cardiac autonomic functions. Aim:To assess and compare the cardiac autonomic functions using PRV in type2 diabetes patients and normal individuals.Material And Methods:The study included 38type2 diabetic individuals and 37 healthy controls. Five minutes PRV was recorded in all the subjects. PRV indices, namely standard deviation of Normal to Normal(SDNN), root mean square of successive differences (RMSSD), total power (TP)and ratio of low to high frequency power of PRV, were calculated.Result:All parameters were summarised using median and interquartile range. Mann-Whitney U test was used to compare median differences in all the parameters between the two groups. Statistically significant differences (p?0.05) were found inSDNN,RMSSD, TP, low frequency (LF) and high frequency (HF) parameters. Median SDNN of controls was 91.8ms with an interquartile range of (58.03 –236.55)ms and in diabetics median SDNN was 21.15ms with an interquartile range of (16.07 –26.92)ms. In controls median total power was 3904ms2 with an interquartile range of (3267 –5370 )ms2. In cases median total power was 1025.50ms2with an interquartile range of (492 –1250) ms2.Conclusion:Decrease in PRV indicates the presence of cardiac autonomic dysfunction in diabetics. Therefore PRV can be used as a simple, non-invasive method for assessing cardiac autonomic function in diabetic individuals.