SEROTONIN ROLE IN FIBROMYALGIA

ABSTRACT

Fibromyalgia (FM) is a musculo-skeletal disorder and tiredness which results in diffuse myalgia, localized pain, weakness, lower pain thresholds and non-restorative sleep. Multiple sources of evidence supporting the view of decreased flux via the serotonin pathway in FM patients. Supplementation with serotonin substrates, through L- tryptophan or 5-Hydroxytryptophan (5-HTP) significantly improves depression symptoms, anxiety, fatigue and poor sleep in FM patients. Advances in fibromyalgia recognition have helped to increase the therapy choices for FM patients. New medications, nutritional supplements, and nutritional / pharmacological improvement of deep-stage sleep are all being studied by researchers that emphasizes awareness, exercise, and serotonin substrate / receptor regulation.