Expression of mismatch repair proteins in urothelial carcinoma of the urinary bladder
Indian J Cancer
;
2022 Jun; 59(2): 279-281
Artigo
| IMSEAR
| ID: sea-221688
ABSTRACT
Background:
Urothelial carcinoma of the urinary bladder (UCUB) is a frequently diagnosed malignancy. Mismatch repair (MMR), a proofreading machinery of the DNA, prevents tumorigenesis. The role of MMR deficiency in UCUB in eastern Indian population is not known.Methods:
Immunohistochemistry panel for MLH1, PMS2, MSH2, and MSH6 (MMR proteins) was performed on the biopsy specimens of UCUB (N=100).Results:
MMR deficiency by immunohistochemistry was demonstrated in two cases (2%). One case showed deficiency of MSH2 and MSH6 and the other case showed the deficiency of all four mismatch proteins. Both cases showed high?grade invasive urothelial carcinoma by histomorphology.Conclusion:
The prevalence of MMR deficiency by immunohistochemistry is 2% in eastern Indian population. Immunohistochemistry
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Índice:
IMSEAR (Sudeste Asiático)
Revista:
Indian J Cancer
Ano de publicação:
2022
Tipo de documento:
Artigo
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