HLA antigen profile in pulmonary tuberculosis patients & their spouses.
Artigo
em Inglês
| IMSEAR
| ID: sea-22193
ABSTRACT
HLA-A, -B, -DR and -DQ antigen profile was studied in pulmonary tuberculosis patients (n = 209) and their spouses (family contacts; n = 50) and healthy volunteers (n = 72). An increased frequency of HLA-A-10, B7, B15, DR2 and DQ1 was seen in the pulmonary-TB (PTB) patients when compared to the total control subjects (n = 122). However, a significant increase was seen only with HLA-DR2 (P < 0.001; Pc < 0.01; Relative Risk 2.3) and -DQ1 (P < 0.005; Pc < 0.015; Relative Risk 2.8). Among the spouses and the corresponding patients, a similar increase of HLA-DR2 was seen. A decreased frequency of HLA-A19, B8, B17, B35, DR5 and DR6 were seen in PTB as compared to control groups. The present study suggested that HLA-DR2 and DQ1 genes/gene products may be associated with the susceptibility to tuberculosis either alone or in combination with other HLA or non-HLA genes.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tuberculose Pulmonar
/
Feminino
/
Humanos
/
Masculino
/
Antígenos HLA-DQ
/
Antígeno HLA-DR2
/
Cônjuges
/
Adulto
/
Antígenos HLA
Tipo de estudo:
Estudo de etiologia
Idioma:
Inglês
Ano de publicação:
1998
Tipo de documento:
Artigo
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