Thymectomy for myasthenia gravis: A pathological analysis
Indian J Pathol Microbiol
;
2022 Mar; 65(1): 129-132
Artigo
| IMSEAR
| ID: sea-223183
ABSTRACT
Background:
Myasthenia gravis (MG) is a prototypic T-cell-dependent antibody-mediated autoimmune disease that leads to ocular or generalized muscular weakness. The disease is most commonly caused by antibodies to the acetylcholine receptors, often with underlying thymic pathology.Aims:
This study is aimed at analyzing the pathological spectrum of the excised thymuses in patients with myasthenia. Materials andMethods:
This was a retrospective 10-year study of 68 thymectomy specimens performed as a part of the treatment of patients with MG. StatisticalAnalysis:
Nil.Results:
There were 47 males and 21 females (male to female ratio of 2.21) with a mean age of 41 years. Only three patients presented with ocular myasthenia. The thymus was normal in 9 patients (13.2%) and atrophic in 17 patients (25%). Follicular hyperplasia and thymomas were seen in 6 and 36 patients, respectively.Conclusion:
The thymectomies performed in patients of MG had a fairly variable spectrum on histology; the thymic tumors were predominantly of the cortical phenotype.
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Índice:
IMSEAR (Sudeste Asiático)
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2022
Tipo de documento:
Artigo
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