Immunohistochemical evaluation of E-cadherin in oral epithelial dysplasia and squamous cell carcinoma
Indian J Pathol Microbiol
;
2022 Dec; 65(4): 755-760
Artigo
| IMSEAR
| ID: sea-223339
ABSTRACT
Aim:
To evaluate the expression of E-cadherin (E-cad) in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material andMethod:
Immunohistochemistry was used to detect E-cad expression in 20 cases each of normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Statistical Analysis Used Inferential statistical methods for statistical analysis used were Chi-square test for comparison of the frequency between different severity of dysplasia and OSCC.Results:
Upon assessing the expression of E-cad in OED and OSCC, increase in E-cad immunoreactivity was seen in early lesions. However, the expression of E-cad decreased significantly as the grade of dysplasia increased.Conclusion:
We observed a significant decrease in E-cad expression from dysplasia to poorly differentiated squamous cell carcinoma suggesting that loss of expression of E-cad is closely related to carcinoma.
Texto completo:
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Índice:
IMSEAR (Sudeste Asiático)
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2022
Tipo de documento:
Artigo
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