Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma
Indian J Pathol Microbiol
;
2022 Dec; 65(4): 809-813
Artigo
| IMSEAR
| ID: sea-223349
ABSTRACT
Background:
Dual specificity phosphatase 4 (DUSP4), which regulates the mitogen activated protein kinases, has emerged as a tumor suppressor gene in several human malignancies. Aims andObjectives:
In this study, we investigated the clinicopathologic significance and the prognostic role of DUSP4 in gallbladder adenocarcinoma. Materials andmethods:
DUSP4 expression was evaluated immunohistochemically in tissue microarray from 110 gallbladder adenocarcinoma samples and scored by H score system. The cut off (H score <170) was determined by ROC curve analysis.Results:
Low expression of DUSP4 expression was observed in 57 (51.8%) out of 110 gallbladder adenocarcinoma samples. Low expression of DUSP4 expression was significantly associated with high histologic grade (P = 0.017), high pT stage (P = 0.002) and high AJCC stage (P = 0.007). Kaplan Meier survival curves revealed that patients with low expression of DUSP4 expression had significantly worse cancer specific survival (P = 0.024, log rank test). However, there was no significant association between DUSP4 expression and recurrence free survival.Conclusions:
In conclusion, gallbladder adenocarcinoma with low expression of DUSP4 expression was associated with adverse clinicopathologic characteristics and poor patient outcome.patient outcome.
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Índice:
IMSEAR (Sudeste Asiático)
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2022
Tipo de documento:
Artigo
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