Study of antibiogram pattern of organisms isolated from urinary tract infections from a tertiary care hospital from central India

ABSTRACT

Introduction: Urinary tract infections (UTI) are the most common infection encountered in the life of an individual irrespective of age and sex. Varying degree of antibiotic resistance shown by uropathogens against the routinely used antibiotics in the therapeutic regimen is a serious concern in treatment of UTI. This study was aimed at the isolation and demonstration of antibiogram pattern of organism responsible for acute UTI. Materials and methods: Clean catched mid stream urine (CCMSU) specimens collected from patients of different age group were cultured on blood agar and Mac Conkey’s agar by standard loop culture method. These organisms were further identified by standard methods and antibiotic sensitivity was evaluated using Kirby Bauers disc diffusion method in accordance with CLSI guidelines. Results: A total of 1230 samples were collected from both males and females of age group 5 to 80. Among the total, 443 (36%) samples were positive for culture and showed significant bacteruria. Gram negative isolates were responsible for majority of infection and 86.9% isolates and Escherichia coli was the predominant among them (37.2%). Conclusion: Majority of the isolates showed resistance to drugs commonly used to treat UTI. Variations in sensitivity may be due to the inappropriate exposure of different localities as to antibiotics which can drive the development of resistance. From the results of this study, it is certain that choosing drugs for empiric treatment will be challenging as no single common drug can conveniently be recommended for UTI.