Red cell phosphoglycerate kinase in insulin-dependent diabetes mellitus.
Artigo
em Inglês
| IMSEAR
| ID: sea-23357
ABSTRACT
Red cell phosphoglycerate kinase (PGK) activity was determined in normal individuals and patients with, type I (insulin-dependent) diabetes and insulin treated diabetes. The PGK activity was significantly (P less than 0.001) elevated in diabetes, however it is restored to normalcy after insulin treatment (normal 282.54 +/- 9.46, type I diabetic 342.06 +/- 6.24, insulin treated diabetic 292.66 +/- 7.12 IU/g haemoglobin at 37 degrees C). No significant alteration was observed in the percentage of PGK bound to the membrane fraction of red cells in all the three conditions. The results indicate that the increased PGK activity is a result of a regulatory mechanism induced by the fluctuation of ATP level in response to elevated NaK pump rate of erythrocytes in type I diabetes mellitus.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfoglicerato Quinase
/
Humanos
/
Diabetes Mellitus Tipo 1
/
Eritrócitos
/
Insulina
Idioma:
Inglês
Ano de publicação:
1990
Tipo de documento:
Artigo
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