Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats.
Hindustan Antibiot Bull
;
2002 Feb-Nov; 44(1-4): 53-9
Artigo
em Inglês
| IMSEAR
| ID: sea-2339
ABSTRACT
Rhinax, a polyherbal formulation, exhibited hepatoprotective function when tested against antitubercular drug-induced hepatotoxicity in rats. Suppression of GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and glutathione S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in cytochrome P-450 contents and increased production of lipid peroxidation. Rhinax afforded hepatoprotection by inhibiting lipid peroxidation and, as a result, the animals showed improved antioxidant status.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Masculino
/
Extratos Vegetais
/
Peroxidação de Lipídeos
/
Ratos Wistar
/
Medicina Herbária
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fígado
/
Testes de Função Hepática
/
Animais
Idioma:
Inglês
Revista:
Hindustan Antibiot Bull
Ano de publicação:
2002
Tipo de documento:
Artigo
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