Immunoreactivity of mycobacterial 70 kDa protein in different physico-chemical forms.
Artigo
em Inglês
| IMSEAR
| ID: sea-24117
ABSTRACT
The immunoreactivity of 70 kDa culture filtrate protein of Mycobacterium tuberculosis H37 Ra has been examined as such and by increasing its hydrophobicity through its conjugation to stearic acid ester (70 kDa-FAester). The cell mediated immune responses produced by 70 kDa-FAester encapsulated in phosphatidylcholine (PC) liposomes were significantly higher particularly at the 3rd week post immunization (wk p. im.) than that produced by the 70 kDa protein in PC liposomes, whereas humoral immune responses were non-significant. Further, these immune responses were comparable to that elicited by 70 kDa protein complexed with Freund's incomplete adjuvant (70 kDa-FIA). Results of this study suggest that changes in physicochemical nature of 70 kDa protein influences both the humoral and cellular immunoreactivity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfatidilcolinas
/
Proteínas de Bactérias
/
Ensaio de Imunoadsorção Enzimática
/
Adjuvantes Imunológicos
/
Lipossomos
/
Animais
/
Camundongos
/
Mycobacterium tuberculosis
/
Antígenos
Idioma:
Inglês
Ano de publicação:
1997
Tipo de documento:
Artigo
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