Epidermal calmodulin levels in psoriasis before & after therapy.
Artigo
em Inglês
| IMSEAR
| ID: sea-24136
ABSTRACT
Epidermal calmodulin (CaM) levels were measured in the involved and uninvolved skin in 26 psoriasis patients before and after treatment either with dithranol topically or methotrexate orally. The mean epidermal calmodulin levels (+/- SD) in the involved and uninvolved psoriatic skin before treatment were 21.99 +/- 10.22 and 11.97 +/- 3.50 in the patients to be treated with short contact dithranol therapy (SCDT) while it was 19.46 +/- 8.13 and 11.27 +/- 7.23 in the patients to be treated with systemic methotrexate. Clearance of psoriatic lesions was associated with a significant fall (P less than 0.05) in epidermal calmodulin, activity irrespective of the treatment modality used. Also, there was a significant reduction (P less than 0.05) in the calmodulin levels in the epidermis of uninvolved skin following successful treatment.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Psoríase
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Calmodulina
/
Esquema de Medicação
/
Antralina
/
Metotrexato
/
Adolescente
Idioma:
Inglês
Ano de publicação:
1991
Tipo de documento:
Artigo
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